In order to ensure the barrier function of the skin, mutual regulation of connections between skin cells and a receptor for growth factors is required. The findings may help to reduce the consequences of inflammatory skin diseases as well as the diminished skin barrier function in old age. The mechanism was described by scientists around Carien Niessen from the Cluster of Excellence CECAD for Aging Research in Cologne. Their findings are published in the journal Nature Communications. The epidermis is our most important protection from the outside world. Our ability to survive depends on keeping it intact. For this barrier to be maintained, every single cell needs to know what it is doing.
The study, conducted in close collaboration with scientists from the Max Planck Institute for Biology of Aging (Sara Wickström) and Universities in Yale (Aaron Mertz) and Tokyo (Masayuki Amagai, Akiharu Kubo) on mice with defects at the skin barrier was published in the journal Nature Communications.
Original Publication:" E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning "Matthias Rübsam, Aaron F. Mertz, Akiharu Kubo, Susanna Marg, Christian Jüngst, Gladiola Goranci-Buzhala, Astrid C. Schauss, Valerie Horsley, Eric R. Dufresne, Markus Moser, Wolfgang Ziegler, Masayuki Amagai, Sara A. Wickström, and Carien M. Niessen
Nature Communications DOI: 10.1038 / s41467-017-01170-7
You can find the photo under the following link:- https://portal.uni-koeln.de/fileadmin/sites/uni/images/Pressemitteilunge...
Caption: Cells in the uppermost layers of skin form tight connections (gray) to regulate the transport of molecules and water. The nuclei of the cells are colored here.
Photo: Matthias Rübsam
Article Link :- https://www.nature.com/articles/s41467-017-01170-7
Further information:- cecad.uni-koeln.de/